| First Lady or First Gentleman | Governor | Date tenure began | Date tenure ended | Date of death (age) | Notes |
|---|
| 1 | | Inés Mendoza | Luis Muñoz Marín | January 2, 1949 | January 2, 1965 | (1990-08-13)August 13, 1990 (82) | Mendoza was the second wife of Puerto Rico's first directly elected governor, Luis Muñoz Marín, whom she married in 1946.
She remains the longest serving first lady in Puerto Rico's history. |
| 2 | Conchita Dapena | Roberto Sánchez Vilella | January 2, 1965 | 1967 | (2003-02-25)February 25, 2003[3] | First Lady Conchita Dapena and Governor Roberto Sánchez Vilella separated in March 1967 after his affair with his legislative aide, Jeannette Ramos Buonomo, became public.[4][5] They had been married for 31 years before their divorce.[4] Governor Sánchez Vilella's affair and divorce from First Lady Dapena is credited with ending his political career.[5] |
| 3 | Jeannette
|